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    師資隊伍

    細胞生物學與生物物理學系

    李桂英

    日期:2020-08-11 點擊數: 來源:

          名:

    李桂英

          稱:

    教授 博士生導師

    最高學位:

    博士

        話:

    0431-85155222

          件:

    ligy@jlu.edu.cn

    工作地點:

    生命科學樓228

    研究方向

    酶與細胞增殖調控及腫瘤生物治療:

    1. 細胞周期蛋白依賴性蛋白激酶及其相互作用因子在細胞增殖調控中作用機制研究

    2. 胞內基因工程抗體研制及腫瘤生物治療

    3. 肝損傷及修復分子機制

    4. 腫瘤生物標志物的發現及腫瘤早期診斷

    教育經歷

    1997.9-2000.7 東北師范大學遺傳與細胞研究所,獲理學博士學位

    1994.9-1997.7 東北師范大學遺傳與細胞研究所,獲理學碩士學位

    1990.9-1994.7 東北師范大學生命科學學院,獲理學學士學位

    工作經歷

    2008.9-至今 吉林大學分子酶學工程教育部重點實驗室,教授,博士生導師

    2014.1-2014.4 美國科羅拉多大學丹佛分校藥學院,高級研究學者

    2007.1-2008.2 美國匹茲堡大學醫學院,訪問學者

    2003.9-2008.9 吉林大學分子酶學工程教育部重點實驗室,副教授,碩士生導師

    2000.9-2003.9 吉林大學基礎醫學院免疫學系,基礎醫學博士后,20033月特評特聘為副教授。

    榮譽稱號

    《臨床肝膽病雜志》編委

    教育部“新世紀優秀人才”

    吉林省首批中青年科技創新領軍人才

    吉林省拔尖創新人才

    吉林省首批學科領軍教授

    研究成果

    近年來先后主持國家自然科學基金等省部級以上課題18項(含教育部新世紀優秀人才計劃等4項人才計劃項目),已授權發明專利2項和受理發明專利3項(第一發明人),在Hepatology,J Hepatol,Cell ResSCI收錄雜志和國內重要學術刊物上發表文章50余篇,參與撰寫專著1部。以第一完成人身份完成的科研成果榮獲“吉林省自然科學獎”二等獎1項、吉林省自然科學學成果獎一等獎1項、吉林省自然科學學成果獎二等獎1項、吉林省科學技術進步獎三等獎1項等9項獎勵。代表性成果如下:

    1.  A   PSTAIRE-like protein is localized in nuclei and cytoplasm of Physarum   polycephalum and functions in the mitosis. Cell Res,2004, 14 (2): 169-175

    2.  Cyclooxygenase-2   prevents Fas-induced liver injury through up-regulation of epidermal growth   factor receptor. Hepatology, 2009, 503: 834-843.

    3.    Cytosolic   phospholipase A2α and PPAR-γ signaling pathway counteracts TGF-β-mediated   inhibition of primary and transformed hepatocyte growth. Hepatology,   2010, 52(2): 644-655.

    4.    Cytosolic   phospholipase A2α protects against Fas-but not LPS-induced liver injury. J   Hepatol, 2011, 55(6):1281-1290.

    5.    Characterization   of the interaction between eupatorin and bovine serum albumin by   spectroscopic and molecular modeling methods. Int J Mol Sci,   2013, 14(7): 14185-14203.

    6.    Role of   hepatic resident and infiltrating macrophages in liver repair after acute   injury. Biochem Pharmacol, 2013, 86(6): 836-843.

    7.    16p13.3 duplication associated with non-syndromic   pierre robin sequence with incomplete penetrance. Mol Cytogenet,2014, 7(1)76

    8.    Interaction   of AIM with insulin-like growth factor-binding protein-4. Int J Mol Med,   2015, 36(3): 833-838.

    9.    Molecular   characterization of 20 small supernumerary marker chromosome cases using   array comparative genomic hybridization and fluorescence in situ   hybridization. Sci Rep, 2017, 7(1):10395. doi:   10.1038/s41598-017-10466-z.

    10. Exosome   separation using microfluidic systems: size-based, immunoaffinity-based and   dynamic methodologies. Biotechnol J, 2017, DOI:   10.1002/biot.201600699

    11. Role of   gp91phox in hepatic macrophage programming and alcoholic liver   disease. Hepatol Commun, 2017, 1(8): 765-779.

    12. Prokaryotic   expression, purification and characterization of human cyclooxygenase-2. Int   J Mol Med, 2017, 40:75-82.

    13. Effects of   metal ions on the structure and activity of a human anti-cyclin D1   single-chain variable fragment AD5. Mol Med Reports, 2017,   16:1314-1320.

    14. New cofactors and inhibitors for a   DNA-cleaving DNAzyme: superoxide anion and hydrogen peroxide mediated an   oxidative cleavage process. Sci Rep, 2017, 7(1): 378. doi:   10.1038/s41598-017-00329-y.

    15. Subunits   of human condensins are potential therapeutic targets for cancers. Cell Div, 2018, 13: 2.

    16. Extraction   of cell-free whole blood plasma using a dielectrophoresis - based   microfluidic device. Biotechnol J, 2019, 14(3): 1800181.

    17. Intrabody against   prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible   factor-1α. Sci Rep, 2019, 9(1):11861.

    18. TRIM59 loss in M2 macrophages promotes melanoma migration and   invasion by upregulating MMP-9 and Madcam1. Aging   (Albany NY), 2019, 11(19):8623-8641.

    19. TRIM59:   A membrane protein expressed on Bacillus Calmette-Guérin-activated   macrophages that induces apoptosis of fibrosarcoma cells by direct contact. Exp   Cell Res, 2019, 384(1):111590.

    20. Intrabody   against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver   injury in mice via concomitant promotion of angiogenesis and redox   homeostasis. Biomed Pharmacother, 2020, 123:109783.

    21. Cancer   liquid biopsy using integrated microfluidic exosome analysis platforms.   Biotechnol J, 2020, 15(5):1900225.

    22. Separation   of macrophages using a dielectrophoresis-based microfluidic device. BioChip J , 2020, 14(2): 185–194.

    23. A cyclin   D1-specific single-chain variable fragment antibody that inhibits HepG2 cell   growth and proliferation. Biotechnol J, 2020, 15(8):1900430.

    24. 一種腫瘤細胞特異性真核表達載體,中國,發明專利,ZL 200410011191.8

    25. 種抗腫瘤人源單鏈抗體,中國,發明專利,ZL 201010104607.6

    26. 一種內置透明電極的全透明微流控芯片及其制備方法, 中國,發明專利,ZL 201710644638.2

    27. 一種實現全血血漿持續分離的微流控器件及其分離方法, 中國,發明專利,ZL 201710644637.8

    28. 一種人源單鏈抗體及其應用,中國,發明專利,ZL 201711449190.5

    29. 一種抗環氧合酶人源單鏈抗體. 專利申請號:201310507280.0

    30. 一種人源單鏈抗體及其應用. 專利申請號:201711449190.5

    31. 《合成生物學與合成酶學》. 科學出版社,2012

     

    怡红院院
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