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    當前位置: 首頁 > 師資隊伍 > 教授 > 生物工程系 > 正文
    師資隊伍

    生物工程系

    謝秋宏

    日期:2020-08-11 點擊數: 來源:
    謝秋宏
    姓名: 謝秋宏
    職稱: 教授
    最高學位: 博士
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    工作地點: 吉林大學生命科學學院
    研究方向: 研究方向: (1)資源微生物與生物轉化; (2)蛋白質工程與健康。 主要研究課題: ① 益生菌資源開發、機制研究與應用; ② 微生物轉化中藥新功能物質的發現及其性質研究; ③ 腸道微生物組與免疫應答機制研究; ④ 共存微生物發酵體系的開發及其應用; ⑤ 蛋白質結構功能研究及靶向藥物篩選與生物藥創制。
    教育經歷: 1995.09-1998.02 中國科學院 沈陽應用生態研究所 微生物學專業 博士
    1989.09-1992.07 吉林大學 分子生物學系 生物化學與分子生物學專業 碩士
    1985.09-1989.07 山東大學 微生物學系 微生物學專業 學士

    工作經歷: 2008.04-今 吉林大學生命科學學院 教授
    2004.10-2008.03 日本動物衛生研究所 研究員
    2001.10-2004.09 日本食品綜合研究所 研究員
    2001.04-2001.09 日本國際科學振興財團生物研究所 研究員
    1999.04-2001.03 日本工業技術院生命工學工業技術研究所 研究員
    1998.04-1999.03 日本關西學院大學理學部 研究員
    1998.09-1999.03 吉林大學生命科學學院 副教授
    1994.07-1998.08 吉林大學生命科學學院 講 師
    1992.07-1994.06 吉林大學生命科學學院 助 手

    研究成果: 近5年發表SCI論文13篇,申請專利8件,其中2件已獲得專利授權;先后主持省部級科研項目8項,其中1項通過省科技廳主持的項目鑒定;主講本科生課程3門,研究生課程1門;培養碩士博士研究生20人。2015年作為主要發起人和申請人,申請"吉林省轉化生物學與健康工程研究中心",獲得吉林省發改委批準立項。
    1. Pan T, Xiang H, Diao T, Ma W, Shi C, Xu Y, Xie Q. Effects of probiotics and nutrients addition on the microbial community and fermentation quality of peanut hull. Bioresour Technol. 2018 Nov 2; 273:144-152. doi: 10.1016/j.biortech.2018.10.088.
    2. Wang Y, Xie Q, Sun S, Huang B, Zhang Y, Xu Y, Zhang S, Xiang H. Probiotics-fermented Massa Medicata Fermentata ameliorates weaning stress in piglets related to improving intestinal homeostasis. Appl Microbiol Biotechnol. 2018 Nov 5. doi: 10.1007/s00253-018-9438-y.
    3. Zhang Y, Xiang H, Sun L, Xie Q, Liu M, Chen Y, Ruan S. A Sensor Based on LiCl/NaA Zeolite Composites for Effective Humidity Sensing. Journal of Nanoscience and Nanotechnology. 2018, 18: 1882-1886.
    4. Hu W, Xie Q, Liu L, Xiang H. Enhanced Bioactivity of the Anti-LOX-1 scFv Engineered by Multimerization Strategy. Appl Biochem Biotechnol. 2017 Nov 9. doi: 10.1007/s12010-017-2649-3.
    5. Hu W, Xie Q, Xiang H. Improved scFv Anti-LOX-1 Binding Activity by Fusion with LOX-1-Binding Peptides. Biomed Res Int. 2017; 2017:8946935. doi: 10.1155/2017/8946935.
    6. Gao X, Xie Q, Kong P, Liu L, Sun S, Xiong B, Huang B, Yan L, Sheng J, Xiang H. Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice. Infect Immun. 2017 86(1) pii: e00601-17.
    7. Gao X, Xie Q, Liu L, Kong P, Sheng J, Xiang H. Metabolic adaptation to the aqueous leaf extract of Moringa oleifera Lam.-supplemented diet is related to the modulation of gut microbiota in mice. Appl Microbiol Biotechnol., 2017 101(12): 5115-5130.
    8. Hu W, Xiang JY, Kong P, Liu L, Xie Q, Xiang H. Expression and characterization of a single-chain variable fragment against human LOX-1 in Escherichia coli and Brevibacillus choshinensis. J Microbiol Biotechnol., 2017 27(5): 965-974.
    9. Meng Z, Xie Q, Liu Y, Zhang X, Xiang H. Cellulase Production and Saccharification of Steam-exploded Corn Stover by Mutant Strain Trichoderma reesei EBUV-3. Int. J Agric. Biol., 2016 18(1): 213-17.
    10. Chen C, Xiang JY, Hu W, Xie YB, Wang TJ, Cui JW, Xu Y, Liu Z, Xiang H, Xie Q. Identification of key micro-organisms involved in Douchi fermentation by statistical analysis and their use in an experimental fermentation. J Applied Microbio., 2015 119(5): 1324-34.
    11. Liu Y, Meng Z, Shi R, Zhan L, Hu W, Xiang H, Xie Q. Effects of temperature and additives on the thermal stability of glucoamylase from Aspergillus niger. J Microbiol Biotechnol. 2015 25(1):33-43.
    12. Xu Y, Xie YB, Zhang XR, Chen C, Xiang H, Xie Q. Monitoring of the bacterial and fungal biodiversity and dynamics during Massa Medicata Fermentata fermentation. Appl Microbiol Biotechnol., 2013 97(22): 9647-55.
    13. Liu Y, Li QS, Zhu HL, Meng ZL, Xiang H, Xie Q. Purification and characterization of two thermostable glucoamylases produced by Aspergillus niger B-30. Chem. Res. Chinese Universities, 2013 29(5): 917-23.
    14. Kumano-Kuramochi M, Xie Q, Kajiwara S, Komba S, Minowa T, Machida S. Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis. Biochem Biophys Res Commun. 2013 May 10; 434(3):594-9.
    15. Kumano-Kuramochi M, Shimozu Y, Wakita C, Ohnishi-Kameyama M, Shibata T, Matsunaga S, Takano-Ishikawa Y, Watanabe J, Goto M, Xie Q, Komba S, Uchida K, Machida S. Identification of 4-hydroxy-2-nonenal-histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1. Biochem J. 2012 Feb 15; 442(1):171-80.
    16. Matsunaga S, Xie Q, Kumano-Kuramochi M, Komba S, Machida S. Silicone-urethane adhesive for improved coverslip mounting and leak-free preparation of living cell observation chambers. Biotechniques. 2009 Mar; 46(3):225-7.
    17. Kumano-Kuramochi M, Xie Q, Sakakibara Y, Niimi S, Sekizawa K, Komba S, Machida S. Expression and characterization of recombinant C-terminal biotinylated extracellular domain of human receptor for advanced glycation end products (hsRAGE) in Escherichia coli. J Biochem. 2008 Feb; 143(2):229-36.
    18. Matsunaga S, Xie Q, Kumano M, Niimi S, Sekizawa K, Sakakibara Y, Komba S, Machida S. Lectin-like oxidized low-density lipoprotein receptor (LOX-1) functions as an oligomer and oligomerization is dependent on receptor density. Exp Cell Res. 2007 Apr 1; 313(6):1203-14.
    19. Takahashi H1, Arai M, Takenawa T, Sota H, Xie QH, Iwakura M. Stabilization of hyperactive dihydrofolate reductase by cyanocysteine-mediated backbone cyclization. J Biol Chem. 2007 Mar 30; 282(13):9420-9. Epub 2007 Jan 30.
    20. Xie Q, Matsunaga S, Wen Z, Niimi S, Kumano M, Sakakibara Y, Machida S. In vitro system for high-throughput screening of random peptide libraries for antimicrobial peptides that recognize bacterial membranes. J Pept Sci. 2006 Oct; 12(10):643-52.
    21. Ohki I, Ishigaki T, Oyama T, Matsunaga S, Xie Q, Ohnishi-Kameyama M, Murata T, Tsuchiya D, Machida S, Morikawa K, Tate S. Crystal structure of human lectin-like, oxidized low-density lipoprotein receptor 1 ligand binding domain and its ligand recognition mode to OxLDL. Structure. 2005 Jun; 13(6):905-17.
    22. Xie Q, Matsunaga S, Niimi S, Ogawa S, Tokuyasu K, Sakakibara Y, Machida S. Human lectin-like oxidized low-density lipoprotein receptor-1 functions as a dimer in living cells. DNA Cell Biol. 2004 Feb; 23(2):111-7.
    23. Xie Q, Matsunaga S, Shi X, Ogawa S, Niimi S, Wen Z, Tokuyasu K, Machida S. Refolding and characterization of the functional ligand-binding domain of human lectin-like oxidized LDL receptor. Protein Expr Purif. 2003 Nov; 32(1):68-74.
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