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    當前位置: 首頁 > 師資隊伍 > 教授 > 生物藥學系 > 正文
    師資隊伍

    生物藥學系

    顧景凱

    日期:2020-08-11 點擊數: 來源:
    顧景凱
    姓名: 顧景凱
    職稱: 教授
    最高學位: 博士
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    Email:
    工作地點: 吉林省長春市前進大街2699號生命科學樓
    研究方向: 藥物代謝動力學;體內藥物分析;生物質譜分析;靶點藥物分析;納米藥物體內多形態成分分析;多糖、ADC及蛋白肽類等生物大分子藥物分析;高分子藥用輔料質量控制與體內評價;新型給藥系統的體內時空命運研究;基于DMPK的新藥設計與開發。
    教育經歷: 1997年至2000年 吉林大學超分子結構與材料國家重點實驗室,博士后。
    1994年至1997年 沈陽藥科大學藥學院,藥物分析,博士;
    工作經歷: 現任吉林大學唐敖慶特聘教授;兼任吉林大學艾滋病疫苗國家工程實驗室、分子酶學工程教育部重點實驗室,教授。
    2012-01-至今,吉林大學,唐敖慶特聘教授
    2003-12-至今,吉林大學,生命科學學院藥物代謝研究中心主任,教授,博士生導師
    2001-09,吉林大學,破格晉升為“激勵崗”教授
    2000-01至2001-09,吉林大學,生命科學學院,副教授

    學術兼職:
    兼任國家藥品監督管理局藥品注冊審評專家咨詢委員會專家;中國醫藥質量管理協會臨床研究質量與評價專業委員會,副主任委員;國家藥品監督管理局“藥用輔料質量研究與評價重點實驗室”學術委員會,委員;國家中醫藥管理局“中藥藥代動力學三級實驗室”,主任;中國生化制藥協會專家委員會,委員;全國工商聯醫藥業商會專家;中國藥理學會:藥物代謝專業委員會、臨床藥理專業委員會、藥物基因組專業委員會、分析藥理專業委員會,常務委員;中國藥學會:藥物分析專業委員會、應用藥理學會專業委員會,常務委員;中國醫藥生物技術協會藥物分析技術分會,常務委員;吉林省藥理學會副理事長;中國質譜學會有機質譜專業委員會,委員;美國化學會(ACS),會員;國際藥物及化學異物代謝學會(ISSX),會員。
    榮譽稱號: 吉林大學“唐敖慶”特聘教授
    吉林大學“十一五”科技突出貢獻獎。
    軍隊特需新藥臨床研究關鍵技術平臺構建與應用,中國人民解放軍總后勤部,省部級二等獎,2011
    研究成果: 主持科研項目:
    1. 國家自然科學基金委員會,重點項目,No.81430087, 橋接細胞與整體的納米藥代動力學研究,2015-01至2019-12, 320萬元,已結題,主持;
    2. 國家衛生健康委員會,“十一五”重大新藥創制專項,2009ZX09304-003,臨床前藥物代謝動力學技術平臺(子課題),2009-01至2010-12, 326.16萬元,已結題,主持;
    3. 國家衛生健康委員會,“十三五”重大新藥創制專項,2017ZX09101001,藥物一致性評價關鍵技術與標準研究子課題“離子淌度串聯質譜突破體內藥物分析強干擾瓶頸:極低劑量藥物BE一致性評價新技術”, 2017-01至2020-12, 260萬元,在研,主持;
    4. 江蘇省科技成果轉化專項資金,BA2010147,治療老年性癡呆的1.1類化學新藥-琥珀八氫氨吖啶片的臨床研究及產業化,2010至2016,600萬元,已驗收,主持;
    5. 國家自然科學基金委員會,面上項目,No.81872831,基于質譜新技術的PEG-PLA紫杉醇納米膠束體內多形態成分的精準分析,2019-01至2022-12,57萬元,在研,主持;
    6. 國家自然科學基金委員會,面上項目,No.81673396,基于SWATH技術的PEG化藥物LC-HR-MS/MS分析方法研究與應用,2017-01至2020-12,70萬元,在研,主持;
    7. 國家自然科學基金委員會,面上項目,No.30973587,微管靶向型藥物的亞細胞水平藥代動力學研究,2010-01至2012-12,25萬元,已結題,主持;
    8. 國家自然科學基金委員會,面上項目,No.30772613,七葉皂苷四組分同時給藥的代謝機理及相互關系研究,2008-01至2010-12,30萬元,已結題,主持;
    9. 國家自然科學基金委員會,面上項目,No.30070879,關于藥物的葡萄糖醛酸化代謝研究,2001-01至2003-12,15萬元,已結題,主持;
    10. 國家科技部,“十二五”國家科技支撐計劃,2012BAI30B02,維吾爾、哈薩克藥生物活性成分篩選和現代標準組分庫建設(子課題),2012.01至2014.12,30萬元,已結題,主持;
    11. 國家衛計委,“十一五”重大新藥創制專項,2008ZX09101-020,注射用洋參葉總皂苷的臨床研究(子課題),2010-11至2011-10,11萬元,已結題,主持;
    12. 國家科技部國際合作項目,S2010GR0920,通過聯合給藥技術提高青蒿素類藥物的生物利用度、降低瘧疾耐藥性(子課題),2009-9至2011-12,35萬元,已結題,主持;
    13. 國家科技部,“十一五”國家科技支撐計劃,2006BAI11B07,中醫藥診療技術及特色產品應用研究:中醫藥治療糖尿病的代謝組學研究(子課題),2009至2011,28萬元,已結題,主持;
    14. 國家科技部,“十一五”重大新藥創制專項,軍用特需藥課題,2009zxj09014-0097,“動物模型關鍵技術”新藥防耐藥突變濃度檢測與組織內藥物濃度測定(子課題),2009-1至2010-12,30萬元,已結題,主持;
    15. 國家中醫藥管理局,2006BAI09B09-08,中藥緩控釋制劑多組分釋放評價技術及其適宜性應用(子課題),2006-10至2009-10,8萬元,已結題,主持;
    16. 吉林省科技廳,20040412-1,治療老年癡呆的一類新藥神爾洋的研究,2006-01至2007-12,20萬元,已結題,主持。

    橫向課題:
    (一)生物等效性課題
    利馬前列腺素、前列地爾、阿霉素脂質體、兩性霉素B脂質體、PEG-PLA紫杉醇膠束、鹽酸二甲雙胍、佐米曲普坦、左羥丙哌嗪、鹽酸非索非那定、舍曲林、奧美拉唑、替米沙坦、吲噠帕胺、亮菌甲素、米格列醇、阿奇霉素、氨溴索、氨氯地平、格列吡嗪、曲尼司特、多潘立酮、磷霉素鈣、依那普利、氟桂利嗪、阿那曲唑、格列美脲、納美芬、阿莫西林克拉維酸鉀、阿倫磷酸鈉、阿夫唑嗪、雷尼替丁、西沙必利、格列美脲、羅紅霉素、石杉堿甲、愈酚甲麻那敏、氫氯噻嗪、特拉唑嗪、辛伐他汀、左炔諾孕酮、塞洛多辛、瑞格列奈、洛伐他汀、氯雷他定、鹽酸特比萘芬、瑞舒伐他汀鈣、阿戈美拉汀、氯沙坦鉀、結合型雌激素、胡黃連總苷、雷貝拉唑、群多普利、甲磺酸地拉韋啶、鹽酸沙格雷酯。
    (二)臨床藥代動力學課題
    埃他卡林、卡托普利、精氨酸七葉皂苷、重組人胸腺素α1、洛伐他汀、克拉霉素、阿奇霉素、氨咖敏甲麻膠囊、復方纈沙坦分散片、復方酚咖偽麻膠囊、甘草酸二胺、右美沙芬、依卡倍特、匹伐他汀、非洛地平、米屈肼、美托洛爾、普盧利沙星、非索非那定、偽麻黃堿、羥考酮、倍氯米松、硝酸甘油軟膏、氨基葡萄糖、帕拉米韋三水合物、甲萘氫醌二磷酸酯鈉、煙酸、沙利度胺、奧普力農、雷貝拉唑、氯沙坦鉀、依非巴特、蘭地洛爾、注射用頭孢替坦二鈉、注射用左旋泮托拉唑鈉、苯磺酸氨氯地平葉酸、鹽酸頭孢卡品酯、鹽酸氨溴索、鹽酸阿那格雷、伊潘立酮、利馬前列腺素、石杉堿甲、來那度胺、異丙肌苷、氯法拉濱、磷酸瑞格列汀、脯氨酸恒格列、雙環醇等。
    (三)臨床前藥代動力學課題
    PEG-PLA、葡聚糖、原人參二醇、氨芐西林/丙磺舒、水楊酸偽麻黃堿、華洋-001、TJW-01、FY-01、WZA-001、石杉堿甲微球、葫蘆素、WZA-001、JSTHSYY、賴氨酸七葉皂苷鈉、頭孢呋辛/丙磺舒、奧曲肽微球、利拉魯肽、索馬魯肽、曲普瑞林、亮丙瑞林、WZA-001、39肽、益今生、苯胺洛芬、賴氨酸七葉皂苷、偽人參皂苷GQ、秋水仙堿控釋片、利培酮微球、前列地爾膠束、奧曲肽微球、替莫唑胺顱內緩釋植入片、替莫唑胺酯栓、利培酮微球(30L)、次血紅素六肽、LY03005、落新婦苷、帕潘立酮、左旋泮托拉唑鈉、重組人胸腺素α1、胸腺五肽-胸腺七肽、苯胺洛芬滴眼液、卡前列甲酯片、達瑞司他、小檗堿、復達那非、BT100X、右旋蘭索拉唑、艾塞那肽、豬松弛素、青霉素鈉/丙磺舒鈉。

    近五年代表性期刊論文:
    1. Zhang Z, Jiang H, Zhang Y, Zhang D, Fawcett JP, Gu J*. Comprehensive Bioanalysis of Ultrahigh Molecular Weight, Highly Disperse Poly(ethylene oxide) in Rat via Microsolid Phase Extraction and RPLC-Q-Q-TOF Coupled with the MSALL Technique. Anal Chem. 2020; doi: 10.1021/acs.analchem.0c00189.
    2. Zhang Z, Zhang Y, Song S, Yin L, Sun D, Gu J*. Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals. J Sep Sci. 2020; doi: 10.1002/jssc.201901340.
    3. Wang T, Guo Y, He Y, Ren T, Yin L, Fawcett JP, Gu J*, Sun H*. Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein. Acta Pharm Sin B. 2020; doi:10.1016/j.apsb.2020.02.001
    4. Wang H, Zheng M, Gao J, Wang J, Zhang Q, Fawcett JP, He Y*, Gu J*. Uptake and release profiles of PEGylated liposomal doxorubicin nanoparticles: A comprehensive picture based on separate determination of encapsulated and total drug concentrations in tissues of tumor-bearing mice. Talanta.2020; 208:120358.
    5. Yin L, Ren T, Zhao S, Shi M*, Gu J*. Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MSALL technique. Talanta. 2020; 206: 120184.
    6. Su C, Liu Y, Li R, Wu W, Fawcett JP, Gu J*. Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems. Adv Drug Deliv Rev. 2019; 143: 97-114.
    7. Yin L, Zhang Z, Liu Y, Gao Y, Gu J*. Recent advances in single-cell analysis by MSspectrometry. Analyst. 2019;144:824-845.
    8. Yin L, Feng Y, Tong J, Guo Z, Zhang Y, Zhang Q, Sun Y, Fawcett JP, Gu J*. Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study. Anal Bioanal Chem. 2019;411:5139-5148.
    9. Wang T, Yin L, Wang H, Fawcett JP, Gu J*. Development and application of a high-throughput liquid chromatography-tandem mass spectrometric method for the simultaneous determination of thymosin α1 and its recombinant human form in plasma and urine. J Pharm Biomed Anal. 2019;170:16-21.
    10. Ren T, Zhang Z, Fawcett JP, Sun D*, Gu J*. Micro-solid phase extraction and LC-MS3 for the determination of triptorelin in rat plasma and application to a pharmacokinetic study. J Pharm Biomed Anal. 2019;166:13-19.
    11. Zhang Z, Li R, Liu S, Yin L, Xu T, Fawcett JP, Gu J*. Liquid chromatography tandem mass spectrometry with triple stage fragmentation for highly selective analysis and pharmacokinetics of alarelin in rat plasma. J Sep Sci. 2019;42:3033-3040.
    12. Liang C, Sun H, Meng X, Yin L, Fawcett JP, Yu H, Liu T, Gu J*. Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry. Acta Pharm Sin B. 2018;8:228-234.
    13. Lin W, Yin L, Sun T, Wang T, Xie Z, Gu J*, Jing X*. The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines. Biomacromolecules. 2018;19:1625-1634.
    14. Su C, Liu Y, He Y*, Gu J*. Analytical methods for investigating in vivo fate of nanoliposomes: A review. J Pharm Anal. 2018;8:219-225.
    15. Sun D, Su C, Liu Y, Meng X, Fawcett JP, Guo Y, Gu J*. A Unique Collision-Induced Dissociation Reaction of Cholamine Derivatives of Certain Prostaglandins. J Am Soc Mass Spectrom. 2018;29:2360-2367.
    16. Sun D, Meng X, Ren T, Fawcett JP, Wang H, Gu J*. Establishment of a Charge Reversal Derivatization Strategy to Improve the Ionization Efficiency of Limaprost and Investigation of the Fragmentation Patterns of Limaprost Derivatives Via Exclusive Neutral Loss and Survival Yield Method. J Am Soc Mass Spectrom. 2018; 29:1365 -1375.
    17. Su C, Yang H, Sun H, Fawcett JP, Sun D*, Gu J*. Bioanalysis of free and liposomal Amphotericin B in rat plasma using solid phase extraction and protein precipitation followed by LC-MS/MS. J Pharm Biomed Anal. 2018;158:288-293.
    18. Ren T, Li R, Meng X, Fawcett JP, Sun D*, Gu J*. Differential mobility spectrometry followed by tandem mass spectrometry with multiple ion monitoring for bioanalysis of eptifibatide in rat plasma. J Pharm Biomed Anal. 2018 ;151:260-265.
    19. Zhou X#, Meng X#, Cheng L, Su C, Sun Y, Sun L, Tang Z, Fawcett JP, Yang Y*, Gu J*. Development and Application of an MSALL-Based Approach for the Quantitative Analysis of Linear Polyethylene Glycols in Rat Plasma by Liquid Chromatography Triple-Quadrupole/Time-of-Flight Mass Spectrometry. Anal Chem. 2017;89:5193-5200.
    20. Cong Y, Hu L*, Zhang Z, Gao Y, Dong M, Qin H, Ye M*, Gu J, Zou H. Analysis of therapeutic monoclonal antibody glycoforms by mass spectrometry for pharmacokinetics study.Talanta,2017, 165:664-670.
    21. Yin L, Su C, Ren T, Meng X, Shi M, Paul Fawcett J, Zhang M, Hu W, Gu J*. MSALL strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra. Analyst. 2017 ;142:4279-4288.
    22. Su C, Sun H, Yang H, Yin L, Zhang J, Fawcett JP, Gu J*. A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study. Anal Bioanal Chem. 2017;409:6559-6565.
    23. Meng X, Xu H, Zhang Z, Fawcett JP, Li J, Yang Y*, Gu J*. Differential mobility spectrometry tandem mass spectrometry with multiple ion monitoring for the bioanalysis of liraglutide. Anal Bioanal Chem. 2017;409:4885-4891.
    24. Sun H, Zhang Q, Zhang Z, Tong J, Chu D*, Gu J*. Simultaneous quantitative analysis of polyethylene glycol (PEG), PEGylated paclitaxel and paclitaxel in rats by MS/MSALL technique with hybrid quadrupole time-of-flight mass spectrometry. J Pharm Biomed Anal. 2017;145:255-261.
    25. Su C, Yang H, Meng X, Fawcett JP, Cao J, Yang Y*, Gu J*. Determination of rabeprazole enantiomers in dog plasma by supercritical fluid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. J Sep Sci, 2017, 40:1010- 1016.
    26. Lu H, Su C, Yin L, Gu L, Gu J*, Chen X*. Liquid chromatography-tandem mass spectrometry method for simultaneous determination of valproic acid and its ene-metabolites in epilepsy patient plasma. J Pharm Anal. 2016; 6: 112-116.
    27. Yang Z, Xu X, Sun L, Zhao X, Wang H, Fawcett JP, Yang Y*, Gu J*. Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2016, 1020: 36-42.
    28. Sun H, Wang J, Sun Y, Peng W, Sun L, Yang Y*, Gu J*. Rapid and sensitive liquid chromatography with tandem mass spectrometry method for the simultaneous quantification of yonkenafil and its major metabolites in rat plasma. J Sep Sci. 2016, 39:3700-3708.
    29. Yang Z, Sun L, Liang C, Xu Y, Cao J, Yang Y*, Gu J. Simultaneous quantitation of the diastereoisomers of scholarisine and 19-epischolarisine, vallesamine, and picrinine in rat plasma by supercritical fluid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study. J Sep Sci. 2016, 39:2652-60.
    30. Yang Z, Wang L, Xu M, Gu J, Yu L, Zeng S*. Simultaneous analysis of gemfibrozil, morphine, and its two active metabolites in different mouse brain structures using solid-phase extraction with ultra-high performance liquid chromatography and tandem mass spectrometry with a deuterated internal standard. J Sep Sci. 2016; 39:2087-96.
    31. Yin L, Wang T, Shi M, Zhang Y, Zhao X, Yang Y*, Gu J*. Simultaneous determination of ten antiepileptic drugs in human plasma by liquid chromatography and tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in therapeutic drug monitoring. J Sep Sci. 2016,39:964-72.

    專利:
    1. 顧景凱;尹磊;任天明;趙式櫻;史美云;林文孩;景遐斌。一種PEG及PEG化藥物的分析檢測方法及其應用:中國, CN201710706546.2. 2018-01-16.
    2. 顧景凱;孟祥駿;趙式櫻;張琪;僮金;尹磊。一種定量測定生物樣品中前列腺素的方法:中國, CN201710707523.3. 2018-01-19.
    3. 顧景凱;徐學宇;王浩;趙雪。一種噻吩并吡啶類衍生物硫酸氫鹽的晶型Ⅲ及其制備方法和應用:中國,CN201710700259.0. 2017-11-24.
    4. 顧景凱;徐學宇;王浩;趙雪。一種噻吩并吡啶類衍生物硫酸氫鹽的晶型Ⅱ及其制備方法和應用:中國,CN201710700262.2. 2019-08-16.
    5. 顧景凱;張揚;楊志超;尹磊。一種腦靶向艾司利卡西平酯類前藥及其應用:中國,CN201611039363.1. 2019-09-27.
    6. 顧景凱;周曉彤;程龍妹;尹磊;楊艷。一種生物樣本中PEG含量的測定方法:中國,CN201510356323.9. 2017-03-29.
    7. 顧景凱;尹磊;史美云;孟祥駿;宿崇;彭雯雯;陸歡;林文孩;楊艷;景遐斌。一種生物樣本中PEG化藥物的定量測定方法:中國,CN201510356568.1. 2017-04-05.
    8. 顧景凱;張揚;楊艷;趙森;楊智超;楊弘;宿崇。腦靶向O-去甲基文拉法辛酚酯類前藥及制備方法和用途:中國, CN201310527939.9. 2015-07-22.

    出版專著:
    《緩控釋制劑藥物動力學》,科學出版社,2009年,合作主編
    《臨床藥物動力學》,科學出版社,2010年,編委

    學術會議:
    1. Studies on the Fate of Nano-drug Delivery System in vivo, 4TH Ling-Nan International Forum on DMPK,廣州,2019.
    2. LC-MS for Bioanalysis of Therapeutic Peptides, Polymer Excipient and Nano-DDS, CPSA(Pharnaceutical Solutions through Analysis), 上海,2019.
    3. Studies on DMPK of Nano-Carriers in vivo, The 2nd International Symposium on Advances in Pharmaceutical Analysis,法國里爾市,2018.
    4. ASMS Conference on Mass Spectrometry and Allied Topics,美國加利福尼亞州,圣地亞哥市,2018.
    5. ASMS Conference on Mass Spectrometry and Allied Topics,美國印第安納州,印第安納波利斯市,2017.
    6. DMPK of Nano-DDS: Challenge and Our Strategies, Asian Federation of Pharmaceutical Sciences Conference 2017,廈門,2017.
    7. Development of LC-HR-MS/MS with the swath technique for pharmacokinetic studies of PEG and pegylated drugs, 27th International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2016),廣州,2016.
    怡红院院
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